Title : Activation of TGF-β pathway by areca nut constituents: a possible cause of oral submucous fibrosis.

Pub. Date : 2012

PMID : 23284772






2 Functional Relationships(s)
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1 Moreover, both polyphenols and alkaloids induced TGF-beta2 and THBS1 (activator of latent TGF-beta) in HaCaT cells suggesting areca nut mediated activation of p-SMAD2 involves up-regulation and activation of TGF-beta. Alkaloids transforming growth factor beta 1 Homo sapiens
2 Moreover, both polyphenols and alkaloids induced TGF-beta2 and THBS1 (activator of latent TGF-beta) in HaCaT cells suggesting areca nut mediated activation of p-SMAD2 involves up-regulation and activation of TGF-beta. Alkaloids transforming growth factor beta 1 Homo sapiens