Title : A histone deacetylase inhibitor, largazole, decreases liver fibrosis and angiogenesis by inhibiting transforming growth factor-β and vascular endothelial growth factor signalling.

Pub. Date : 2013 Apr

PMID : 23279742






5 Functional Relationships(s)
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1 A histone deacetylase inhibitor, largazole, decreases liver fibrosis and angiogenesis by inhibiting transforming growth factor-beta and vascular endothelial growth factor signalling. largazole vascular endothelial growth factor A Mus musculus
2 Largazole also inhibited the expression of vascular endothelial growth factor (VEGF) and its receptor. largazole vascular endothelial growth factor A Mus musculus
3 Largazole also inhibited the expression of vascular endothelial growth factor (VEGF) and its receptor. largazole vascular endothelial growth factor A Mus musculus
4 VEGF-induced proliferation of HSCs and activation of Akt and p38MAPK were also suppressed by largazole. largazole vascular endothelial growth factor A Mus musculus
5 Furthermore, largazole inhibited angiogenesis in vivo as evidenced by reduced expression of CD34, VEGF and VEGFR. largazole vascular endothelial growth factor A Mus musculus