Title : Design, synthesis and evaluation of novel heterodimers of donepezil and huperzine fragments as acetylcholinesterase inhibitors.

Pub. Date : 2013 Feb 1

PMID : 23273608






1 Functional Relationships(s)
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1 Heterodimers comprised of dimethoxyindanone (from donepezil), hupyridone (from HupA), and connected with a multimethylene linker, were identified as potent and selective inhibitors of AChE. 5-amino-5,6,7,8-tetrahydroquinolin-2(1H)-one acetylcholinesterase (Cartwright blood group) Homo sapiens