Title : Deletion of Mthfd1l causes embryonic lethality and neural tube and craniofacial defects in mice.

Pub. Date : 2013 Jan 8

PMID : 23267094






1 Functional Relationships(s)
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1 In light of previous studies linking a common splice variant in the human MTHFD1L gene with increased risk for NTDs, this mouse model provides a powerful system to help elucidate the specific metabolic mechanisms that underlie folate-associated birth defects, including NTDs. Folic Acid methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like Homo sapiens