Title : The STAT5 Inhibitor Pimozide Displays Efficacy in Models of Acute Myelogenous Leukemia Driven by FLT3 Mutations.

Pub. Date : 2012 Jul

PMID : 23264850






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Pimozide inhibits the tyrosine phosphorylation of STAT5, leading to the death of AML cells through the induction of apoptosis. Tyrosine signal transducer and activator of transcription 5A Mus musculus
2 Pimozide shows a combinatorial effect with the tyrosine kinase inhibitors midostaurin (PKC412) and sunitinib in the inhibition of STAT5 tyrosine phosphorylation and the induction of apoptosis. Tyrosine signal transducer and activator of transcription 5A Mus musculus