Title : Preventive effects of epigallocatechin-3-O-gallate against replicative senescence associated with p53 acetylation in human dermal fibroblasts.

Pub. Date : 2012

PMID : 23259030






3 Functional Relationships(s)
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1 Preventive effects of epigallocatechin-3-O-gallate against replicative senescence associated with p53 acetylation in human dermal fibroblasts. epigallocatechin gallate tumor protein p53 Homo sapiens
2 The involvement of Sirt1 and acetylated p53 was examined as an underlying mechanism for the senescence preventive activity of EGCG in HDFs. epigallocatechin gallate tumor protein p53 Homo sapiens
3 Furthermore, EGCG was found to prevent serial passage- and H(2)O(2)-induced senescence in HDFs by suppressing p53 acetylation, but the Sirt1 activity was unaffected. epigallocatechin gallate tumor protein p53 Homo sapiens