Pub. Date : 2012 Dec 18
PMID : 23256041
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Doxorubicin blocks proliferation of cancer cells through proteolytic activation of CREB3L1. | Doxorubicin | cAMP responsive element binding protein 3 like 1 | Homo sapiens |
| 2 | Here we report that doxorubicin stimulates de novo synthesis of ceramide, which in turn activates CREB3L1, a transcription factor synthesized as a membrane-bound precursor. | Doxorubicin | cAMP responsive element binding protein 3 like 1 | Homo sapiens |
| 3 | Doxorubicin stimulates proteolytic cleavage of CREB3L1 by Site-1 Protease and Site-2 Protease, allowing the NH(2)-terminal domain of CREB3L1 to enter the nucleus where it activates transcription of genes encoding inhibitors of the cell cycle, including p21. | Doxorubicin | cAMP responsive element binding protein 3 like 1 | Homo sapiens |
| 4 | Doxorubicin stimulates proteolytic cleavage of CREB3L1 by Site-1 Protease and Site-2 Protease, allowing the NH(2)-terminal domain of CREB3L1 to enter the nucleus where it activates transcription of genes encoding inhibitors of the cell cycle, including p21. | Doxorubicin | cAMP responsive element binding protein 3 like 1 | Homo sapiens |
| 5 | Knockdown of CREB3L1 mRNA in human hepatoma Huh7 cells and immortalized human fibroblast SV589 cells conferred increased resistance to doxorubicin, whereas overexpression of CREB3L1 in human breast cancer MCF-7 cells markedly enhanced the sensitivity of these cells to doxorubicin. | Doxorubicin | cAMP responsive element binding protein 3 like 1 | Homo sapiens |
| 6 | Knockdown of CREB3L1 mRNA in human hepatoma Huh7 cells and immortalized human fibroblast SV589 cells conferred increased resistance to doxorubicin, whereas overexpression of CREB3L1 in human breast cancer MCF-7 cells markedly enhanced the sensitivity of these cells to doxorubicin. | Doxorubicin | cAMP responsive element binding protein 3 like 1 | Homo sapiens |
| 7 | These results suggest that measurement of CREB3L1 expression may be a useful biomarker in identifying cancer cells sensitive to doxorubicin.DOI:http://dx.doi.org/10.7554/eLife.00090.001. | Doxorubicin | cAMP responsive element binding protein 3 like 1 | Homo sapiens |