Title : Glutathione S-transferase activity, sulfhydryl group and glutathione levels, and DNA cross-linking activity with chlorambucil in chronic lymphocytic leukemia.

Pub. Date : 1990 May 2

PMID : 2325147






3 Functional Relationships(s)
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Protein Name
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1 An inverse correlation was observed between GST activity and cross-linking by chlorambucil, which was enhanced if both GST activity and GSH level were related to cross-linking. Chlorambucil glutathione S-transferase kappa 1 Homo sapiens
2 An inverse correlation was observed between GST activity and cross-linking by chlorambucil, which was enhanced if both GST activity and GSH level were related to cross-linking. Chlorambucil glutathione S-transferase kappa 1 Homo sapiens
3 These findings suggest that the combination of GST and GSH protects the DNA of leukemia cells from chlorambucil, but the role of this combination in clinical resistance remains to be determined. Chlorambucil glutathione S-transferase kappa 1 Homo sapiens