Title : Induction of endoplasmic reticulum stress by sorafenib and activation of NF-κB by lestaurtinib as a novel resistance mechanism in Hodgkin lymphoma cell lines.

Pub. Date : 2013 Feb

PMID : 23243060






1 Functional Relationships(s)
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1 Sorafenib inhibited platelet-derived growth factor receptor (PDGFR) alpha, TRKA and RON, caused decreases in total and phosphorylated amounts of several signaling molecules, and provoked caspase-3-independent cell death, most likely due to endoplasmic reticulum stress as indicated by upregulation of GADD34 and GADD153 and phosphorylation of PERK. Sorafenib caspase 3 Homo sapiens