Title : Metformin limits the tumourigenicity of iPS cells without affecting their pluripotency.

Pub. Date : 2012

PMID : 23236586






2 Functional Relationships(s)
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1 Mechanistically, metformin appears to suppress the Oct4-driven compartment of malignant stem cells responsible for teratocarcinoma growth while safeguarding an intact, Oct4-independent competency to generate terminally differentiated tissues. Metformin POU domain, class 5, transcription factor 1, related sequence 1 Mus musculus
2 Mechanistically, metformin appears to suppress the Oct4-driven compartment of malignant stem cells responsible for teratocarcinoma growth while safeguarding an intact, Oct4-independent competency to generate terminally differentiated tissues. Metformin POU domain, class 5, transcription factor 1, related sequence 1 Mus musculus