Title : Dual role of an N-terminal amyloidogenic mutation in apolipoprotein A-I: destabilization of helix bundle and enhancement of fibril formation.

Pub. Date : 2013 Jan 25

PMID : 23233678






1 Functional Relationships(s)
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1 Our results indicate dual critical roles of the arginine residue at position 26 in apoA-I(Iowa): destabilization of the N-terminal helix bundle structure in full-length protein and enhancement of amyloid fibril formation by the N-terminal 1-83 fragment. Arginine apolipoprotein A1 Homo sapiens