Pub. Date : 2012
PMID : 23231391
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Part II- discovery of MAO-B inhibitors based on nitrogen heterocycles and analogues. | Nitrogen | monoamine oxidase B | Homo sapiens |
| 2 | Different families of nitrogen and oxygen heterocycles, such as pyrazoles, hydrazinylthiazoles, xanthones, coumarins or chromones have also been extensively used as scaffolds in medicinal chemistry programs for searching novel MAO-B inhibitors. | Nitrogen | monoamine oxidase B | Homo sapiens |
| 3 | Nitrogen derivatives play a key role in this subject with several studies pointing out hydrazines, thiazoles or indoles as important scaffolds for the development of novel MAO-B inhibitors. | Nitrogen | monoamine oxidase B | Homo sapiens |
| 4 | This review comprises an overview of the state of the art on the actual pharmacological therapy for PD followed by a specific focus on the discovery and development of nitrogen-based heterocyclic compounds analogues as promising MAO-B inhibitors. | Nitrogen | monoamine oxidase B | Homo sapiens |