Title : The adaptor protein Grb2 is not essential for the establishment of the glomerular filtration barrier.

Pub. Date : 2012

PMID : 23226445






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 A number of proteins reside in the slit diaphragm, notably the transmembrane proteins Nephrin and Neph1, which are both able to act as tyrosine phosphorylated scaffolds that recruit cytoplasmic effectors to initiate downstream signaling. Tyrosine kirre like nephrin family adhesion molecule 1 Mus musculus
2 While association between tyrosine-phosphorylated Neph1 and the SH2/SH3 adaptor Grb2 was shown in vitro to be sufficient to induce actin polymerization, in vivo evidence supporting this finding is still lacking. Tyrosine kirre like nephrin family adhesion molecule 1 Mus musculus