Title : Hybrid fluorescent conjugates of COX-2 inhibitors: search for a COX-2 isozyme imaging cancer biomarker.

Pub. Date : 2013 Jan 1

PMID : 23200247






1 Functional Relationships(s)
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1 Within this group of compounds, the ibuprofen-acridone conjugate (10) showed potent and selective COX-2 inhibition (COX-2 IC(50)=0.67 muM; SI=110.6), but its fluorescence emission (lambda(em)=417, 440 nm) was not suitable for fluorescent imaging of cancer cells that over-express the COX-2 isozyme. acridone latexin Homo sapiens