Title : Studies on the interaction mechanism of pyrene derivatives with human tumor-related DNA.

Pub. Date : 2012 Nov 28

PMID : 23192191






2 Functional Relationships(s)
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1 In this work, the interactions of two selected pyrene derivatives (1-OHP and 1-PBO) and human tumor-related DNA (p53 DNA and C-myc DNA) are investigated by spectroscopic and non-native polyacrylamide gel electrophoresis (PAGE) methods. pyrene MYC proto-oncogene, bHLH transcription factor Homo sapiens
2 Besides, the binding of pyrene derivatives to p53 DNA is stronger than that for C-myc DNA. pyrene MYC proto-oncogene, bHLH transcription factor Homo sapiens