Title : Polyamine pathway inhibition as a novel therapeutic approach to treating neuroblastoma.

Pub. Date : 2012

PMID : 23181218






2 Functional Relationships(s)
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1 Inhibition of ODC1 by difluoromethylornithine (DFMO) decreased tumor penetrance in TH-MYCN mice treated pre-emptively, and extended survival and synergized with chemotherapy in treating established tumors in both TH-MYCN and xenograft models. Eflornithine ornithine decarboxylase, structural 1 Mus musculus
2 Inhibition of ODC1 by difluoromethylornithine (DFMO) decreased tumor penetrance in TH-MYCN mice treated pre-emptively, and extended survival and synergized with chemotherapy in treating established tumors in both TH-MYCN and xenograft models. Eflornithine ornithine decarboxylase, structural 1 Mus musculus