Pub. Date : 2013 Jan 5
PMID : 23178521
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Anti-inflammatory activity of anatabine via inhibition of STAT3 phosphorylation. | anatabine | signal transducer and activator of transcription 3 | Mus musculus |
| 2 | We observed that anatabine reduces pro-inflammatory cytokine production (IL-6, IL-1beta and TNF-alpha) in the plasma, kidney and spleen of the animals following the injection of LPS and concomitantly opposes STAT3 phosphorylation induced by LPS in the spleen and kidney. | anatabine | signal transducer and activator of transcription 3 | Mus musculus |
| 3 | Moreover, an increased STAT3 phosphorylation was detected in the brains of Tg APPsw mice compared to wild-type littermates and was inhibited by anatabine treatment. | anatabine | signal transducer and activator of transcription 3 | Mus musculus |
| 4 | Overall our data show that the anti-inflammatory activity of anatabine in vitro and in vivo is mediated in part via an inhibition of STAT3 phosphorylation. | anatabine | signal transducer and activator of transcription 3 | Mus musculus |