Title : The serum miR-21 level serves as a predictor for the chemosensitivity of advanced pancreatic cancer, and miR-21 expression confers chemoresistance by targeting FasL.

Pub. Date : 2013 Jun

PMID : 23177026






4 Functional Relationships(s)
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1 miR-21 expression in cancer tissue has been reported to be associated with the clinical outcome and activity of gemcitabine in pancreatic cancer. gemcitabine microRNA 21 Homo sapiens
2 We tested the levels of serum miR-21 in a cohort of 177 cases of advanced pancreatic cancer who received gemcitabine-based palliative chemotherapy. gemcitabine microRNA 21 Homo sapiens
3 The results from a functional study showed that gemcitabine exposure down-regulated miR-21 expression and up-regulated FasL expression. gemcitabine microRNA 21 Homo sapiens
4 The increased FasL expression following gemcitabine treatment induced cancer cell apoptosis, whereas the ectopic expression of miR-21 partially protected the cancer cells from gemcitabine-induced apoptosis. gemcitabine microRNA 21 Homo sapiens