Pub. Date : 2013 Feb
PMID : 23169578
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The UBIAD1 prenyltransferase links menaquinone-4 [corrected] synthesis to cholesterol metabolic enzymes. | Cholesterol | UbiA prenyltransferase domain containing 1 | Homo sapiens |
| 2 | Schnyder corneal dystrophy (SCD) is an autosomal dominant disease characterized by germline variants in UBIAD1 introducing missense alterations leading to deposition of cholesterol in the cornea, progressive opacification, and loss of visual acuity. | Cholesterol | UbiA prenyltransferase domain containing 1 | Homo sapiens |
| 3 | We show UBIAD1 interacts with HMGCR and SOAT1, enzymes catalyzing cholesterol synthesis and storage, respectively, using yeast two-hybrid screening and immunoprecipitation. | Cholesterol | UbiA prenyltransferase domain containing 1 | Homo sapiens |
| 4 | Docking simulations indicate cholesterol binds to UBIAD1 in the substrate-binding cleft and substrate-binding overlaps with GGPP binding, an MK-4 substrate, suggesting potential competition between these metabolites. | Cholesterol | UbiA prenyltransferase domain containing 1 | Homo sapiens |
| 5 | Impaired MK-4 synthesis is a biochemical defect identified in SCD suggesting UBIAD1 links vitamin K and cholesterol metabolism through physical contact between enzymes and metabolites. | Cholesterol | UbiA prenyltransferase domain containing 1 | Homo sapiens |