Title : The DNA methyltransferase inhibitor zebularine induces mitochondria-mediated apoptosis in gastric cancer cells in vitro and in vivo.

Pub. Date : 2013 Jan 4

PMID : 23167995






2 Functional Relationships(s)
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1 A zebularine concentration of 50 muM accounted for the inhibition of cell proliferation of 67% at 48 h. The treatment with zebularine upregulated Bax, and decreased Bcl-2 protein. pyrimidin-2-one beta-ribofuranoside BCL2 associated X, apoptosis regulator Homo sapiens
2 A zebularine concentration of 50 muM accounted for the inhibition of cell proliferation of 67% at 48 h. The treatment with zebularine upregulated Bax, and decreased Bcl-2 protein. pyrimidin-2-one beta-ribofuranoside BCL2 associated X, apoptosis regulator Homo sapiens