Pub. Date : 2013 Jun
PMID : 23161900
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | VEGF/Ang2 induced EC function was assessed using transwell invasion chambers, matrigel tube formation assays and wound repair scratch assays+-Notch-1 siRNA or an gamma-secretase inhibitor N-(N-(3,5-Difluorophenacetyl-L-alanly))-S-phenylglycine-t-Butyl Ester (DAPT) in RA synovial explants or human microvascular EC. | dapt | angiopoietin 2 | Homo sapiens |
| 2 | Furthermore VEGF/Ang2-induced EC invasion, angiogenesis and migration were inhibited by Notch-1 siRNA or DAPT. | dapt | angiopoietin 2 | Homo sapiens |
| 3 | Conditioned media from VEGF/Ang2 stimulated RA synovial explants induced EC tube formation, an effect that was inhibited by DAPT. | dapt | angiopoietin 2 | Homo sapiens |
| 4 | Finally, DAPT significantly decreased VEGF/Ang2 induced IL-6, IL-8, MMP2 and 9 expressions in RA synovial explants. | dapt | angiopoietin 2 | Homo sapiens |