Title : [Mechanism of p38 mitogen-activated protein kinase inhibitor SB203580 to glucocorticoid sensitivity].

Pub. Date : 2012 Sep 25

PMID : 23158801






3 Functional Relationships(s)
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1 RESULTS: The mRNA expression of GR was 0.671 +- 0.002 in cigarette smoke exposure to asthmatic group and 0.595 +- 0.061 in SB203580 group (P = 0.065). SB 203580 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus
2 The protein expression of GR was 0.700 +- 0.033 in cigarette smoke exposure to asthmatic group and 0.628 +- 0.091 in SB203580 group (P = 0.148). SB 203580 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus
3 CONCLUSION: The mechanism of SB203580 enhancing the corticosteroid sensitivity may be improving nuclear translocation of GR to elevate corticosteroid sensitivity. SB 203580 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus