Title : GTPases IF2 and EF-G bind GDP and the SRL RNA in a mutually exclusive manner.

Pub. Date : 2012

PMID : 23150791






3 Functional Relationships(s)
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1 GTPases IF2 and EF-G bind GDP and the SRL RNA in a mutually exclusive manner. Guanosine Diphosphate G elongation factor mitochondrial 1 Homo sapiens
2 We show that binding of IF2 and EF-G to a 27 nucleotide RNA fragment mimicking the sarcin-ricin loop is mutually exclusive with that of GDP, but not of GTP, providing a mechanism for destabilization of the ribosome-bound GDP forms of translational GTPases. Guanosine Diphosphate G elongation factor mitochondrial 1 Homo sapiens
3 We show that binding of IF2 and EF-G to a 27 nucleotide RNA fragment mimicking the sarcin-ricin loop is mutually exclusive with that of GDP, but not of GTP, providing a mechanism for destabilization of the ribosome-bound GDP forms of translational GTPases. Guanosine Diphosphate G elongation factor mitochondrial 1 Homo sapiens