Title : Influence of FMO1 and 3 polymorphisms on serum olanzapine and its N-oxide metabolite in psychiatric patients.

Pub. Date : 2013 Dec

PMID : 23147717






4 Functional Relationships(s)
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1 Influence of FMO1 and 3 polymorphisms on serum olanzapine and its N-oxide metabolite in psychiatric patients. Olanzapine flavin containing dimethylaniline monoxygenase 1 Homo sapiens
2 We investigated the influence of FMO1 and 3 polymorphisms on the steady state serum concentrations of OLA and its N-oxide metabolite in 379 patients. Olanzapine flavin containing dimethylaniline monoxygenase 1 Homo sapiens
3 The upstream FMO1*6 was associated with increased dose-adjusted serum OLA concentrations (C/Ds; P=0.008), an effect further enhanced by FMO1rs7877C>T in smokers. Olanzapine flavin containing dimethylaniline monoxygenase 1 Homo sapiens
4 The upstream FMO1*6 was associated with increased dose-adjusted serum OLA concentrations (C/Ds; P=0.008), an effect further enhanced by FMO1rs7877C>T in smokers. Olanzapine flavin containing dimethylaniline monoxygenase 1 Homo sapiens