Title : The targeted inhibition of mitochondrial Hsp90 overcomes the apoptosis resistance conferred by Bcl-2 in Hep3B cells via necroptosis.

Pub. Date : 2013 Jan 1

PMID : 23147571






1 Functional Relationships(s)
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1 Previous studies have reported that a Gamitrinib variant containing triphenylphosphonium (G-TPP) binds to mitochondrial Hsp90 and rapidly inhibits its activity, thus inducing the apoptotic pathway in the cells. Gamitrinib heat shock protein 90 alpha family class A member 1 Homo sapiens