Pub. Date : 2013 Feb
PMID : 23143138
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Sodium arsenite exposure inhibits AKT and Stat3 activation, suppresses self-renewal and induces apoptotic death of embryonic stem cells. | sodium arsenite | thymoma viral proto-oncogene 1 | Mus musculus |
| 2 | We demonstrated that the crucial signaling pathway, which was substantially suppressed by sodium arsenite exposure (4 muM) in ESC, was the PI3K-AKT pathway linked with numerous downstream targets that control cell survival and apoptosis. | sodium arsenite | thymoma viral proto-oncogene 1 | Mus musculus |
| 3 | In summary, our data demonstrated suppression of self-renewal and induction of apoptosis in mouse ESC by sodium arsenite exposure, which was further accelerated due to simultaneous inhibition of the protective PI3K-AKT and Stat3-dependent pathways. | sodium arsenite | thymoma viral proto-oncogene 1 | Mus musculus |