Title : The plasma membrane sialidase NEU3 regulates the malignancy of renal carcinoma cells by controlling β1 integrin internalization and recycling.

Pub. Date : 2012 Dec 14

PMID : 23139422






2 Functional Relationships(s)
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1 The human plasma membrane sialidase NEU3 is a key enzyme in the catabolism of membrane gangliosides, is crucial in the regulation of cell surface processes, and has been demonstrated to be significantly up-regulated in renal cell carcinomas (RCCs). Gangliosides neuraminidase 3 Homo sapiens
2 NEU3 silencing in RCC cells increased the membrane ganglioside content, in particular the GD1a content, and changed the expression of key regulators of the integrin recycling pathway. Gangliosides neuraminidase 3 Homo sapiens