Pub. Date : 2012 Jun 21
PMID : 23124518
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Etoposide sensitizes neuroblastoma cells expressing caspase 8 to TRAIL. | Etoposide | TNF superfamily member 10 | Homo sapiens |
| 2 | We provide evidence that pretreatment with etoposide significantly enhanced TRAIL-mediated apoptosis via up-regulation of DR5 (death receptor 5 or TRAIL-R2) expression in the caspase 8 expressing neuroblastoma cell line, SK-N-MC. | Etoposide | TNF superfamily member 10 | Homo sapiens |
| 3 | In addition, sequential treatment with etoposide and TRAIL increased caspases 8, 9 and 3 activation, Mcl-1 cleavage and Bid truncation, which suggests that the ability of etoposide and TRAIL to induce apoptosis is mediated through activation of an intrinsic signalling pathway. | Etoposide | TNF superfamily member 10 | Homo sapiens |
| 4 | In addition, sequential treatment with etoposide and TRAIL increased caspases 8, 9 and 3 activation, Mcl-1 cleavage and Bid truncation, which suggests that the ability of etoposide and TRAIL to induce apoptosis is mediated through activation of an intrinsic signalling pathway. | Etoposide | TNF superfamily member 10 | Homo sapiens |
| 5 | Although TRAIL-R2 expression increased in IMR-32 cells in response to etoposide treatment, cell death was not increased by concurrent treatment with TRAIL compared with etoposide alone, because the cells lacked caspase 8 expression. | Etoposide | TNF superfamily member 10 | Homo sapiens |
| 6 | Moreover, pretreatment with etoposide increased TRAIL-induced apoptosis in caspase 8 restored IMR-32 cells through activation of a caspase cascade that included caspases 8, 9 and 3. | Etoposide | TNF superfamily member 10 | Homo sapiens |
| 7 | These results indicate that the etoposide-mediated sensitization of neuroblastoma cells to TRAIL is associated with an increase in TRAIL-R2 expression and requires caspase 8 expression. | Etoposide | TNF superfamily member 10 | Homo sapiens |