Title : Inhibitory effects of catechin derivatives on mammalian DNA polymerase and topoisomerase activities and mouse one-cell zygote development.

Pub. Date : 2013 Mar

PMID : 23121921






5 Functional Relationships(s)
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1 Some catechins inhibited mammalian pols (alpha and beta) and human topos (I and II), with (-)-epigallocatechin gallate (EGCg) the strongest inhibitor of both enzyme types, showing IC(50) values of 3.8-21.5 and 2.0-20.0 muM, respectively. epigallocatechin gallate latexin Homo sapiens
2 Some catechins inhibited mammalian pols (alpha and beta) and human topos (I and II), with (-)-epigallocatechin gallate (EGCg) the strongest inhibitor of both enzyme types, showing IC(50) values of 3.8-21.5 and 2.0-20.0 muM, respectively. epigallocatechin gallate latexin Homo sapiens
3 In the mouse one-cell zygote assay, EGCg at 50 muM increased abnormal cells and 75 muM of EGCg-induced apoptosis. epigallocatechin gallate latexin Homo sapiens
4 In the mouse one-cell zygote assay, EGCg at 50 muM increased abnormal cells and 75 muM of EGCg-induced apoptosis. epigallocatechin gallate latexin Homo sapiens
5 In the mouse one-cell zygote assay, EGCg at 50 muM increased abnormal cells and 75 muM of EGCg-induced apoptosis. epigallocatechin gallate latexin Homo sapiens