Pub. Date : 2013 Jan
PMID : 23108376
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | OPA1 downregulation is involved in sorafenib-induced apoptosis in hepatocellular carcinoma. | Sorafenib | OPA1 mitochondrial dynamin like GTPase | Homo sapiens |
| 2 | Treatment with sorafenib induces rapid mitochondrial fragmentation, which is associated with the deregulation of mitochondria fusion-related protein optic atrophy 1 (OPA1). | Sorafenib | OPA1 mitochondrial dynamin like GTPase | Homo sapiens |
| 3 | Treatment with sorafenib induces rapid mitochondrial fragmentation, which is associated with the deregulation of mitochondria fusion-related protein optic atrophy 1 (OPA1). | Sorafenib | OPA1 mitochondrial dynamin like GTPase | Homo sapiens |
| 4 | Our data indicate that siRNA-mediated OPA1 knockdown significantly sensitizes HCC cells to sorafenib-induced apoptosis. | Sorafenib | OPA1 mitochondrial dynamin like GTPase | Homo sapiens |
| 5 | OPA1 expression levels are strongly downregulated by sorafenib treatment. | Sorafenib | OPA1 mitochondrial dynamin like GTPase | Homo sapiens |
| 6 | Taken together, we have shown that sorafenib suppresses the tumorigenesis of HCC through the induction of mitochondrial injury via OPA1. | Sorafenib | OPA1 mitochondrial dynamin like GTPase | Homo sapiens |