Title : Phosphorylation and nitration of tyrosine residues affect functional properties of Synaptophysin and Dynamin I, two proteins involved in exo-endocytosis of synaptic vesicles.

Pub. Date : 2013 Jan

PMID : 23103755






2 Functional Relationships(s)
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1 Here, we have characterized the association between SYP and c-src tyrosine kinase demonstrating that phosphorylation of Tyr(273) in the C-terminal domain of SYP is crucial in mediating SYP binding to and activation of c-src. Tyrosine SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus
2 In addition, we tested DynI self-assembly and GTPase activity, which are enhanced by c-src-dependent tyrosine phosphorylation of DynI, and found that both were inhibited by PN. Tyrosine SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus