Title : Switching diastereoselectivity in proline-catalyzed aldol reactions.

Pub. Date : 2012 Nov 16

PMID : 23101761






2 Functional Relationships(s)
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1 The choice of the anion of an achiral TBD-derived guanidinium salt, used as cocatalyst for proline, allows reacting cycloketones with aromatic aldehydes and preparing either anti- or syn-aldol adducts with very high enantioselectivity. Proline synemin Homo sapiens
2 The origin of the syn diastereoselectivity unfolds from an unusual equilibrium process coupled to the enamine-based catalytic cycle standard for proline. Proline synemin Homo sapiens