Title : Effect of anti-siglec-f antibody and reactive oxygen species blocking on histamine release in urinary bladder of ovalbumin-treated mice.

Pub. Date : 2012 Sep

PMID : 23094217






4 Functional Relationships(s)
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1 Effect of anti-siglec-f antibody and reactive oxygen species blocking on histamine release in urinary bladder of ovalbumin-treated mice. Histamine sialic acid binding Ig-like lectin F Mus musculus
2 This study aimed to evaluate the effects of anti-Siglec-F on plasma and urinary histamine levels in ovalbumin (OVA)-challenged urinary bladder in mice. Histamine sialic acid binding Ig-like lectin F Mus musculus
3 Pretreatment with anti-Siglec-F antibody significantly prevented the increase in urinary histamine release (P<0.05), whereas pretreatment with the IgG antibody control did not. Histamine sialic acid binding Ig-like lectin F Mus musculus
4 CONCLUSIONS: Systemic anti-Siglec-F treatment showed anti-allergic effects at least on local histamine release, particularly in the lower urinary bladder. Histamine sialic acid binding Ig-like lectin F Mus musculus