Title : Role of NF-κB activation in matrix metalloproteinase 9, vascular endothelial growth factor and interleukin 8 expression and secretion in human breast cancer cells.

Pub. Date : 2013 Apr

PMID : 23086737






4 Functional Relationships(s)
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1 The aims of this study were to assess the effects and potential mechanisms of parthenolide on the expression of vascular endothelial growth factor (VEGF), interleukin 8 (IL-8) and matrix metalloproteinase 9 (MMP-9) in human breast cancer cell line MDA-MB-231. parthenolide C-X-C motif chemokine ligand 8 Homo sapiens
2 The aims of this study were to assess the effects and potential mechanisms of parthenolide on the expression of vascular endothelial growth factor (VEGF), interleukin 8 (IL-8) and matrix metalloproteinase 9 (MMP-9) in human breast cancer cell line MDA-MB-231. parthenolide C-X-C motif chemokine ligand 8 Homo sapiens
3 The real-time PCR and Western blot data showed that the expressions of VEGF, IL-8 and MMP-9 were significantly inhibited by parthenolide at both transcription level and protein level in MDA-MB-231 cells. parthenolide C-X-C motif chemokine ligand 8 Homo sapiens
4 Hence, the expression of VEGF, IL-8 and MMP-9 may be suppressed by parthenolide through the inhibition of NF-kappaB DNA-binding activity in MDA-MB-231 cells. parthenolide C-X-C motif chemokine ligand 8 Homo sapiens