Title : An unusual antithrombin-binding heparin octasaccharide with an additional 3-O-sulfated glucosamine in the active pentasaccharide sequence.

Pub. Date : 2013 Jan 15

PMID : 23083208






2 Functional Relationships(s)
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1 The molecular conformation of the octasaccharide-antithrombin complex has been determined by NMR experiments and docking/energy minimization. Octasaccharide serpin family C member 1 Homo sapiens
2 The presence of the second 3-O-sulfated glucosamine in the octasaccharide induced more than one order of magnitude increase in affinity to antithrombin compared to the pentasaccharide AGA*IA. Octasaccharide serpin family C member 1 Homo sapiens