Pub. Date : 2012 Dec
PMID : 23069143
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | This study investigated the role of Rad51 expression in HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin (17-AAG)-induced cytotoxicity in two NSCLC cell lines, A549 and H1975. | tanespimycin | RAD51 recombinase | Homo sapiens |
| 2 | The 17-AAG treatment decreased cellular Rad51 protein and mRNA levels and phosphorylated MKK1/2-ERK1/2 protein levels, and disrupted the HSP90 and Rad51 interaction. | tanespimycin | RAD51 recombinase | Homo sapiens |
| 3 | The 17-AAG treatment decreased cellular Rad51 protein and mRNA levels and phosphorylated MKK1/2-ERK1/2 protein levels, and disrupted the HSP90 and Rad51 interaction. | tanespimycin | RAD51 recombinase | Homo sapiens |
| 4 | The 17-AAG treatment also decreased the NSCLC cells" DNA repair capacity, which was restored by the forced expression of the Flag-Rad51 vector. | tanespimycin | RAD51 recombinase | Homo sapiens |
| 5 | Specific inhibition of Rad51 expression by siRNA further enhanced 17-AAG-induced cytotoxicity. | tanespimycin | RAD51 recombinase | Homo sapiens |
| 6 | In contrast, enhanced ERK1/2 activation by the constitutively active MKK1/2 (MKK1/2-CA) vector significantly restored the 17-AAG-reduced Rad51 protein levels and cell viability. | tanespimycin | RAD51 recombinase | Homo sapiens |
| 7 | The 17-AAG and arachidin-1-induced synergistic cytotoxic effects and decreased DNA repair capacity were abrogated in lung cancer cells with MKK1/2-CA or Flag-Rad51 expression vector transfection. | tanespimycin | RAD51 recombinase | Homo sapiens |