Title : Mislocalization and inhibition of acetyl-CoA carboxylase 1 by a synthetic small molecule.

Pub. Date : 2012 Dec 15

PMID : 23067267






3 Functional Relationships(s)
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1 The results of the present study show that the chromeceptin-MFP-2 complex binds to and inhibits ACC1 (acetyl-CoA carboxylase 1), an enzyme important for the de novo synthesis of malonyl-CoA and fatty acids. Fatty Acids acetyl-Coenzyme A carboxylase alpha Mus musculus
2 The results of the present study show that the chromeceptin-MFP-2 complex binds to and inhibits ACC1 (acetyl-CoA carboxylase 1), an enzyme important for the de novo synthesis of malonyl-CoA and fatty acids. Fatty Acids acetyl-Coenzyme A carboxylase alpha Mus musculus
3 As a result, chromeceptin impairs fatty acid synthesis from acetate where ACC1 is a rate-limiting enzyme. Fatty Acids acetyl-Coenzyme A carboxylase alpha Mus musculus