Title : Platelet protease-activated receptor (PAR)4, but not PAR1, associated with neutral sphingomyelinase responsible for thrombin-stimulated ceramide-NF-κB signaling in human platelets.

Pub. Date : 2013 May

PMID : 23065519






1 Functional Relationships(s)
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1 This study demonstrated that thrombin activated nSMase by binding to PAR4, but not to PAR1, to increase the C24:0-ceramide level, followed by the activation of p38 MAPK-NF-kappaB signaling. Ceramides sphingomyelin phosphodiesterase 2 Homo sapiens