Pub. Date : 2012
PMID : 23056265
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We also found that hCG increased cAMP intracellular levels in BeWo cells in a dose-dependent manner, stimulated cAMP response element (CRE) activity and the cotransfection with an expression plasmid of a dominant negative mutant of CREB caused a significant inhibition of hCG stimulation of leptin promoter activity. | Cyclic AMP | hypertrichosis 2 (generalised, congenital) | Homo sapiens |
| 2 | We also found that hCG increased cAMP intracellular levels in BeWo cells in a dose-dependent manner, stimulated cAMP response element (CRE) activity and the cotransfection with an expression plasmid of a dominant negative mutant of CREB caused a significant inhibition of hCG stimulation of leptin promoter activity. | Cyclic AMP | hypertrichosis 2 (generalised, congenital) | Homo sapiens |
| 3 | These results demonstrate that hCG indeed activates cAMP/PKA pathway, and that this pathway is involved in leptin expression. | Cyclic AMP | hypertrichosis 2 (generalised, congenital) | Homo sapiens |
| 4 | Nevertheless, we found leptin induction by hCG is dependent on cAMP levels. | Cyclic AMP | hypertrichosis 2 (generalised, congenital) | Homo sapiens |
| 5 | We found that specific PKA inhibition by H89 caused a significant increase of hCG leptin induction, suggesting that probably high cAMP levels might inhibit hCG effect. | Cyclic AMP | hypertrichosis 2 (generalised, congenital) | Homo sapiens |
| 6 | We found that specific PKA inhibition by H89 caused a significant increase of hCG leptin induction, suggesting that probably high cAMP levels might inhibit hCG effect. | Cyclic AMP | hypertrichosis 2 (generalised, congenital) | Homo sapiens |
| 7 | We observed that a cAMP analogue that specifically activates Epac (CPT-OMe) stimulated leptin expression by hCG. | Cyclic AMP | hypertrichosis 2 (generalised, congenital) | Homo sapiens |
| 8 | In conclusion, we provide evidence suggesting that hCG induction of leptin gene expression in placenta is mediated not only by activation of the MAPK signaling pathway but also by the alternative cAMP/Epac signaling pathway. | Cyclic AMP | hypertrichosis 2 (generalised, congenital) | Homo sapiens |