Pub. Date : 2012
PMID : 23052189
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Interleukin-24 suppresses the growth of vascular smooth muscle cells by inhibiting H(2)O(2)-induced reactive oxygen species production. | Reactive Oxygen Species | interleukin 24 | Mus musculus |
| 2 | However, the role of IL-24 in ROS-induced VSMC growth has not yet been investigated. | Reactive Oxygen Species | interleukin 24 | Mus musculus |
| 3 | To elucidate the effect of IL-24 on ROS-induced signaling, Western blot analysis was employed. | Reactive Oxygen Species | interleukin 24 | Mus musculus |
| 4 | Interestingly, IL-24 attenuated the H(2)O(2)-induced ROS production by reducing the mitochondrial H(2)O(2) production and enhancing the expression of antioxidant enzymes. | Reactive Oxygen Species | interleukin 24 | Mus musculus |
| 5 | CONCLUSION: These findings suggest a novel mechanism in which IL-24 suppresses the growth of normal VSMCs by inhibiting H(2)O(2)-induced ROS production through the regulation of mitochondrial ROS production and expression of antioxidant enzymes. | Reactive Oxygen Species | interleukin 24 | Mus musculus |
| 6 | CONCLUSION: These findings suggest a novel mechanism in which IL-24 suppresses the growth of normal VSMCs by inhibiting H(2)O(2)-induced ROS production through the regulation of mitochondrial ROS production and expression of antioxidant enzymes. | Reactive Oxygen Species | interleukin 24 | Mus musculus |