Pub. Date : 2012 Oct 16
PMID : 23035244
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We found from in silico screening and confirmed by experiment that lithocholic acid (LCA) binds to the p53 binding sites of both MDM2 and MDM4 with a fivefold preference for MDM4. | Lithocholic Acid | tumor protein p53 | Homo sapiens |
| 2 | We found from in silico screening and confirmed by experiment that lithocholic acid (LCA) binds to the p53 binding sites of both MDM2 and MDM4 with a fivefold preference for MDM4. | Lithocholic Acid | tumor protein p53 | Homo sapiens |
| 3 | The comparison of LCA effects on apoptosis in HCT116 p53(+/+) vs. p53(-/-) cells shows a predominantly p53-mediated induction of caspase-3/7. | Lithocholic Acid | tumor protein p53 | Homo sapiens |