Title : Prevention of JNK phosphorylation as a mechanism for rosiglitazone in neuroprotection after transient cerebral ischemia: activation of dual specificity phosphatase.

Pub. Date : 2013 Jan

PMID : 23032483






4 Functional Relationships(s)
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1 Furthermore, we observed that rosiglitazone increased expression of the dual-specificity phosphatase 8 (DUSP8) protein and messenger RNA in ischemic brain tissue. Rosiglitazone dual specificity phosphatase 8 Mus musculus
2 Furthermore, we observed that rosiglitazone increased expression of the dual-specificity phosphatase 8 (DUSP8) protein and messenger RNA in ischemic brain tissue. Rosiglitazone dual specificity phosphatase 8 Mus musculus
3 Another key finding of the present study was that knockdown of DUSP8 in primary cultured cortical neurons that were subjected to oxygen-glucose deprivation diminished rosiglitazone"s effect on downregulation of JNK phosphorylation. Rosiglitazone dual specificity phosphatase 8 Mus musculus
4 Thus, rosiglitazone"s neuroprotective effect after ischemia is mediated by blocking JNK phosphorylation induced by ischemia via DUSP8 upregulation. Rosiglitazone dual specificity phosphatase 8 Mus musculus