Title : Doxorubicin induces cytotoxicity through upregulation of pERK-dependent ATF3.

Pub. Date : 2012

PMID : 23028726






1 Functional Relationships(s)
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1 Doxorubicin treatment showed the following dose-dependent effects: increase in the secretion of tumor necrosis factor alpha; decrease in the expression of phosphorylated protein kinase A and Bcl-2; and increase in the expression of phosphorylated signal transducer and activator of transcription 3, phosphorylated extracellular signal-regulated kinase (ERK), and ATF3. Doxorubicin tumor necrosis factor Homo sapiens