Title : Activation of the P2X₇ receptor induces migration of glial cells by inducing cathepsin B degradation of tissue inhibitor of metalloproteinase 1.

Pub. Date : 2012 Dec

PMID : 23017058






2 Functional Relationships(s)
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1 In this study, we show that ATP-treated glial cultures from neonatal C57BL/6 mice release and increase MMP-9 activity, which is coupled with a decrease in release of TIMP-1 and an increase in activated cathepsin B within the extracellular space. Adenosine Triphosphate tissue inhibitor of metalloproteinase 1 Mus musculus
2 Treatment with a P2X(7) receptor antagonist prevents ATP-induced MMP-9 activity, inhibition of active cathepsin B release and allows for TIMP-1 to be released from the cell. Adenosine Triphosphate tissue inhibitor of metalloproteinase 1 Mus musculus