Pub. Date : 2012 Sep
PMID : 23013619
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Administration of the JAK/STAT3 inhibitor AZD1480 alone and in combination with cediranib reduced tumor hypoxia and the infiltration of VEGF inhibitor-induced p-STAT3 macrophages. | AZD 1480 | signal transducer and activator of transcription 3 | Homo sapiens |
| 2 | Administration of the JAK/STAT3 inhibitor AZD1480 alone and in combination with cediranib reduced tumor hypoxia and the infiltration of VEGF inhibitor-induced p-STAT3 macrophages. | AZD 1480 | signal transducer and activator of transcription 3 | Homo sapiens |
| 3 | Thus, the combination of AZD1480 with cediranib markedly reduced tumor volume, and microvascular density, indicating that up regulation of the STAT3 pathway can mediate resistance to antiangiogenic therapy and combinational approaches may delay or overcome resistance. | AZD 1480 | signal transducer and activator of transcription 3 | Homo sapiens |