Title : Potentiation of anti-angiogenic activity of heparin by blocking the ATIII-interacting pentasaccharide unit and increasing net anionic charge.

Pub. Date : 2012 Dec

PMID : 23010574

1 Functional Relationships(s)
Compound Name
Protein Name
1 Following up on this finding, we showed that the bidirectional effect of sodium taurocholate conjugation was due to its unique structure, that is, the sterane core hindering the ATIII-binding pentasaccharide unit of LMWH with its bulky and rigid structural characteristics while the terminal sulfate group interacts with VEGF to produce stronger binding. Heparin, Low-Molecular-Weight serpin family C member 1 Homo sapiens