Pub. Date : 2013 Jan 1
PMID : 23002242
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | This study was designed to evaluate the reciprocal regulation of KLF2 by the forkhead transcription factor FOXO1, and the 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor atorvastatin, in hyperglycaemic conditions. | Atorvastatin | Kruppel-like factor 2 | Rattus norvegicus |
| 2 | Interestingly, atorvastatin inhibited FOXO1 by increasing phosphorylation and also by inhibiting nuclear localization and replenished KLF2 in high-glucose conditions. | Atorvastatin | Kruppel-like factor 2 | Rattus norvegicus |
| 3 | Chromatin immunoprecipitation analysis demonstrated that glucose increased whereas atorvastatin decreased FOXO1 binding to the promoter region of the KLF2 gene. | Atorvastatin | Kruppel-like factor 2 | Rattus norvegicus |
| 4 | In the vessels of Otsuka Long-Evans Tokushima Fatty rats, animal models of type 2 diabetes, FOXO1 was activated and KLF2 was suppressed, and this was reversed by atorvastatin treatment. | Atorvastatin | Kruppel-like factor 2 | Rattus norvegicus |
| 5 | High-glucose-induced, FOXO1-mediated KLF2 suppression was reversed by atorvastatin, suggesting that intensive statin treatment could be a therapeutic option in diabetic vascular dysfunction. | Atorvastatin | Kruppel-like factor 2 | Rattus norvegicus |