Pub. Date : 2013 Jan 5
PMID : 23001014
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Of the 12 time-points tested, significant increases in expression levels of NK(1) receptor mRNA in the shrew brainstem occurred at 2 and 28 h post-cisplatin injection, whereas intestinal NK(1) receptor mRNA was increased at 28 h. Shrew brainstem and intestinal substance P mRNA levels also tended to increase during the two phases. | Cisplatin | tachykinin receptor 1 | Homo sapiens |
| 2 | Furthermore, expression levels of NK(1) receptor protein were significantly increased in the brainstem at 2, 8, and 33 h post-cisplatin. | Cisplatin | tachykinin receptor 1 | Homo sapiens |
| 3 | The temporal enhancements in NK(1) receptor protein expression were mirrored by significant increases in the phosphorylation status of the brainstem ERK1/2 at 2, 8, and 33 h post-cisplatin. | Cisplatin | tachykinin receptor 1 | Homo sapiens |
| 4 | Our results indicate associations between cisplatin"s peak immediate- and delayed-phase vomiting frequency with increased: (1) expression levels of NK(1) receptor mRNA and its protein level, and (2) downstream NK(1) receptor-mediated phosphorylation of ERK1/2 and PKA signaling. | Cisplatin | tachykinin receptor 1 | Homo sapiens |
| 5 | Our results indicate associations between cisplatin"s peak immediate- and delayed-phase vomiting frequency with increased: (1) expression levels of NK(1) receptor mRNA and its protein level, and (2) downstream NK(1) receptor-mediated phosphorylation of ERK1/2 and PKA signaling. | Cisplatin | tachykinin receptor 1 | Homo sapiens |