Title : The ADP receptor P2RY12 regulates osteoclast function and pathologic bone remodeling.

Pub. Date : 2012 Oct

PMID : 22996695






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 In platelets, ADP stimulation of P2RY12 resulted in GTPase Ras-related protein (RAP1) activation and subsequent alphaIIbbeta3 integrin activation. Adenosine Diphosphate RAS-related protein 1a Mus musculus
2 Likewise, we found that ADP stimulation induced RAP1 activation in WT and integrin beta3 gene knockout (Itgb3-/-) OCs, but its effects were substantially blunted in P2ry12-/- OCs. Adenosine Diphosphate RAS-related protein 1a Mus musculus