Title : Ketamine potentiates hippocampal neurodegeneration and persistent learning and memory impairment through the PKCĪ³-ERK signaling pathway in the developing brain.

Pub. Date : 2012 Oct 2

PMID : 22985497






3 Functional Relationships(s)
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1 Ketamine potentiates hippocampal neurodegeneration and persistent learning and memory impairment through the PKCgamma-ERK signaling pathway in the developing brain. Ketamine Eph receptor B1 Rattus norvegicus
2 The dose of 75mg/kg of ketamine suppressed p-PKCgamma, p-ERK1/2 and Bcl-2 expression but not t-PKCgamma or t-ERK expression. Ketamine Eph receptor B1 Rattus norvegicus
3 Therefore, these data demonstrate that ketamine at a dose of 75mg/kg in the developing brain results in hippocampal neurodegeneration and persistent learning and memory impairment, which is associated with the PKCgamma-ERK signaling pathway. Ketamine Eph receptor B1 Rattus norvegicus